| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | YEATS2 |
| Gene ID: | 55689 |
| Uniprot ID: | YETS2_HUMAN |
| Immunogen Region: | 130-331 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 130-331 of human YEATS2 (NP_060493.3). |
| Immunogen Sequence: | AETPSANHSESDSLSQHNDF LSDKDNNSNMDIEERLSNNM EQRPSRNTGRDTSRITGSHK TEQRNADLTDETSRLFVKKT IVVGNVSKYIPPDKREENDQ STHKWMVYVRGSRREPSINH FVKKVWFFLHPSYKPNDLVE VREPPFHLTRRGWGEFPVRV QVHFKDSQNKRIDIIHNLKL DRTYTGLQTLGAETVVDVEL HR |
| Function | Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. |
| Protein Name | Yeats Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Yeats Domain-Containing Protein 2 antibodyAnti-YEATS2 antibodyAnti-KIAA1197 antibody |
Information sourced from Uniprot.org