Anti-XRN2 antibody (81-130 aa) (STJ96287)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human XRN2 at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-5 3 exoribonuclease 2 (81-130 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XRN2 |
| Gene ID | 22803 |
| Uniprot ID | XRN2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human XRN2 at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | XRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein. |
Additional Info
| Function | Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites. |
| Protein Name | 5'-3' Exoribonuclease 2Dhm1-Like ProteinDhp Protein |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-5'-3' Exoribonuclease 2 antibodyAnti-Dhm1-Like Protein antibodyAnti-Dhp Protein antibodyAnti-XRN2 antibody |
Information sourced from Uniprot.org