| Tissue Specificity | Expressed in various cell lines and in skin fibroblasts. |
| Post Translational Modifications | ATR-dependent phosphorylation of XPA at Ser-196 is important for cell survival in response to UV damage. Ubiquitinated by HERC2 leading to degradation by the proteasome. |
| Function | Involved in DNA nucleotide excision repair (NER). Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. During NER stimulates the 5'-3' helicase activity of XPD/ERCC2 and the DNA translocase activity of XPB/ERCC3. Connects XPD/ERCC2 and XPB/ERCC3 during NER, retaining DNA near the XPB/ERCC3 active site, and stabilizing the complex in a different conformation than in transcribing TFIIH. |
| Protein Name | Dna Repair Protein Complementing Xp-A CellsXeroderma Pigmentosum Group A-Complementing Protein |
| Database Links | Reactome: R-HSA-5696395Reactome: R-HSA-5696400Reactome: R-HSA-6781823Reactome: R-HSA-6782135 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Dna Repair Protein Complementing Xp-A Cells antibodyAnti-Xeroderma Pigmentosum Group A-Complementing Protein antibodyAnti-XPA antibodyAnti-XPAC antibody |
Information sourced from Uniprot.org
