| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WWOX (1-120) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WWOX |
| Gene ID: |
51741 |
| Uniprot ID: |
WWOX_HUMAN |
| Immunogen Region: |
1-120 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human WWOX (NP_057457.1). |
| Immunogen Sequence: |
MAALRYAGLDDTDSEDELPP GWEERTTKDGWVYYANHTEE KTQWEHPKTGKRKRVAGDLP YGWEQETDENGQVFFVDHIN KRTTYLDPRLAFTVDDNPTK PTTRQRYDGSTTAMEILQGR |
| Tissue Specificity | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
| Post Translational Modifications | Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. Ubiquitinated when phosphorylated by TNK2, leading to its degradation. |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Protein Name | Ww Domain-Containing OxidoreductaseFragile Site Fra16d OxidoreductaseShort Chain Dehydrogenase/Reductase Family 41c Member 1 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-8866904Reactome: R-HSA-8866907 |
| Cellular Localisation | CytoplasmNucleusMitochondrionGolgi ApparatusLysosomePartially Localizes To The MitochondriaTranslocates To The Nucleus Upon Genotoxic Stress Or Tnf StimulationTranslocates To The Nucleus In Response To Tgfb1Isoform 5 And Isoform 6 May Localize In The NucleusLocalized To The Lysosome Probably Upon Binding To Vopp1 |
| Alternative Antibody Names | Anti-Ww Domain-Containing Oxidoreductase antibodyAnti-Fragile Site Fra16d Oxidoreductase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 41c Member 1 antibodyAnti-WWOX antibodyAnti-FOR antibodyAnti-SDR41C1 antibodyAnti-WOX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
