| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WWC2 |
| Gene ID: | 80014 |
| Uniprot ID: | WWC2_HUMAN |
| Immunogen Region: | 160-430 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-430 of human WWC2 (NP_079225.5). |
| Immunogen Sequence: | DPDILKAEISTTRLRVKKLK RELSQMKQELLYKEQGFETL QQIDKKMSGGQSGYELSEAK AILTELKSIRKAISSGEKEK QDLMQSLAKLQERFHLDQNI GRSEPDLRCSPVNSHLCLSR QTLDAGSQTSISGDIGVRSR SNLAEKVRLSLQYEEAKRSM ANLKIELSKLDSEAWPGALD IEKEKLMLINEKEELLKELQ FVTPQKRTQDELERLEAERQ RLEEELLSVRGTPSRALAE |
| Function | Regulator of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. Enhances phosphorylation of LATS1 and YAP1 and negatively regulates cell proliferation and organ growth due to a suppression of the transcriptional activity of YAP1, the major effector of the Hippo pathway. |
| Protein Name | Protein Wwc2Bh-3-Only Member BWw Domain-Containing Protein 2 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein Wwc2 antibodyAnti-Bh-3-Only Member B antibodyAnti-Ww Domain-Containing Protein 2 antibodyAnti-WWC2 antibodyAnti-BOMB antibody |
Information sourced from Uniprot.org