Anti-WT1 antibody [SRM15075] (STJ11109805)

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STJ11109805
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : SRM15075
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity purification
Dilution Range: WB, 1:4000-1:16000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: WT1
Gene ID: 7490
Uniprot ID: WT1_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Tissue Specificity Expressed in the kidney and a subset of hematopoietic cells.
Function Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Protein Name Wilms Tumor Protein
Wt33
Database Links Reactome: R-HSA-9690406
Reactome: R-HSA-9831926
Cellular Localisation Nucleus
Nucleolus
Cytoplasm
Isoforms Lacking The Kts Motif Have A Diffuse Nuclear Location
Shuttles Between Nucleus And Cytoplasm
Isoform 1: Nucleus Speckle
Isoform 4: Nucleus
Nucleoplasm
Alternative Antibody Names Anti-Wilms Tumor Protein antibody
Anti-Wt33 antibody
Anti-WT1 antibody

Information sourced from Uniprot.org

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