| Tissue Specificity | Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication. |
| Protein Name | Tyrosine-Protein Kinase Baz1bBromodomain Adjacent To Zinc Finger Domain Protein 1bWilliams Syndrome Transcription FactorWilliams-Beuren Syndrome Chromosomal Region 10 ProteinWilliams-Beuren Syndrome Chromosomal Region 9 ProteinHwalp2 |
| Database Links | Reactome: R-HSA-5250924Reactome: R-HSA-5693565 |
| Cellular Localisation | NucleusAccumulates In Pericentromeric Heterochromatin During ReplicationCo-Localizes With Pcna At Replication Foci During S PhaseCo-Localizes With Smarca5/Snf2h At Replication Foci During Late-S PhaseAlso Localizes To Replication Foci Independently Of Smarca5/Snf2h And PcnaLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Baz1b antibodyAnti-Bromodomain Adjacent To Zinc Finger Domain Protein 1b antibodyAnti-Williams Syndrome Transcription Factor antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 10 Protein antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 9 Protein antibodyAnti-Hwalp2 antibodyAnti-BAZ1B antibodyAnti-WBSC10 antibodyAnti-WBSCR10 antibodyAnti-WBSCR9 antibodyAnti-WSTF antibody |
Information sourced from Uniprot.org
