Anti-WNT4 antibody (122-351) (STJ110119)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal WNT4 (122-351) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WNT4 |
| Gene ID | 54361 |
| Uniprot ID | WNT4_HUMAN |
| Immunogen Region | 122-351 |
| Immunogen Sequence | FAVTRACSSGELEKCGCDRT VHGVSPQGFQWSGCSDNIAY GVAFSQSFVDVRERSKGASS SRALMNLHNNEAGRKAILTH MRVECKCHGVSGSCEVKTCW RAVPPFRQVGHALKEKFDGA TEVEPRRVGSSRALVPRNAQ FKPHTDEDLVYLEPSPDFCE QDMRSGVLGTRGRTCNKTSK AIDGCELLCCGRGFHTAQVE LAERCSCKFHWCCFVKCRQC QRLVELHTCR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 122-351 of human WNT4 (NP_110388.2). |
Additional Info
| Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings. |
| Protein Name | Protein Wnt-4 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3238698Reactome: R-HSA-373080Reactome: R-HSA-3772470Reactome: R-HSA-4086400Reactome: R-HSA-9831926 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Protein Wnt-4 antibodyAnti-WNT4 antibodyAnti-UNQ426 antibodyAnti-PRO864 antibody |
Information sourced from Uniprot.org