Anti-WNT2B antibody (287-300 aa) [R01-8F5] (STJA0012139)

Name: Anti-WNT2B antibody (287-300 aa) [R01-8F5] (STJA0012139)
SKU: STJA0012139-100
Price: 281.5 GBP
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenA synthetic peptide of human Wnt2b

STJA0012139-100

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Short Description	Rabbit monoclonal anti-Wnt2b (287-300 aa) for use in WB, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ICC/IF
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	R01-8F5
Isotype	IgG
Conjugation	Unconjugated
Concentration	0.3 mg/mL
Purification	Affinity Purified
Dilution Range	WB 1:500-1:1000 IF 1:50-1:200
Formulation	50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol	WNT2B
Gene ID	7482
Uniprot ID	WNT2B_HUMAN
Immunogen	A synthetic peptide of human Wnt2b
Immunogen Region	287-300 aa

Tissue Specificity	Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.
Post Translational Modifications	Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
Function	Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
Protein Name	Protein Wnt-2b Protein Wnt-13
Database Links	Reactome: R-HSA-3238698 Reactome: R-HSA-373080
Cellular Localisation	Secreted Extracellular Space Extracellular Matrix
Alternative Antibody Names	Anti-Protein Wnt-2b antibody Anti-Protein Wnt-13 antibody Anti-WNT2B antibody Anti-WNT13 antibody

Information sourced from Uniprot.org