Anti-WNT2 antibody (26-360) (STJ28427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal WNT2 (26-360) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WNT2 |
| Gene ID | 7472 |
| Uniprot ID | WNT2_HUMAN |
| Immunogen Region | 26-360 |
| Immunogen Sequence | SWWYMRATGGSSRVMCDNVP GLVSSQRQLCHRHPDVMRAI SQGVAEWTAECQHQFRQHRW NCNTLDRDHSLFGRVLLRSS RESAFVYAISSAGVVFAITR ACSQGEVKSCSCDPKKMGSA KDSKGIFDWGGCSDNIDYGI KFARAFVDAKERKGKDARAL MNLHNNRAGRKAVKRFLKQE CKCHGVSGSCTLRTCWLAMA DFRKTGDYLWRKYNGAIQVV MNQDGTGFTVANERFKKPT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-360 of human WNT2 (NP_003382.1). |
Additional Info
| Tissue Specificity | Expressed in brain in the thalamus, in fetal and adult lung and in placenta. |
| Post Translational Modifications | Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition. |
| Function | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons. |
| Protein Name | Protein Wnt-2Int-1-Like Protein 1Int-1-Related ProteinIrp |
| Database Links | Reactome: R-HSA-3238698Reactome: R-HSA-373080 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Protein Wnt-2 antibodyAnti-Int-1-Like Protein 1 antibodyAnti-Int-1-Related Protein antibodyAnti-Irp antibodyAnti-WNT2 antibodyAnti-INT1L1 antibodyAnti-IRP antibody |
Information sourced from Uniprot.org