| Short Description : | Rabbit polyclonal WLS (43-232) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WLS |
| Gene ID: | 79971 |
| Uniprot ID: | WLS_HUMAN |
| Immunogen Region: | 43-232 |
| Immunogen Sequence: | YMSVKCVDARKNHHKTKWFV PWGPNHCDKIRDIEEAIPRE IEANDIVFSVHIPLPHMEMS PWFQFMLFILQLDIAFKLNN QIRENAEVSMDVSLAYRDDA FAEWTEMAHERVPRKLKCTF TSPKTPEHEGRYYECDVLPF MEIGSVAHKFYLLNIRLPVN EKKKINVGIGEIKDIRLVGI HQNGGFTKVW |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 43-232 of human WLS (NP_001002292.3). |
| Post Translational Modifications | N-glycosylated. |
| Function | Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. |
| Protein Name | Protein Wntless HomologIntegral Membrane Protein Gpr177Protein Evenness Interrupted HomologEviPutative Nf-Kappa-B-Activating Protein 373 |
| Database Links | Reactome: R-HSA-3238698 |
| Cellular Localisation | Golgi Apparatus MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneCell MembraneEndoplasmic Reticulum MembraneEarly Endosome MembraneCo-Localizes With The Adaptin Ap2a2 At Distinct Punctae |
| Alternative Antibody Names | Anti-Protein Wntless Homolog antibodyAnti-Integral Membrane Protein Gpr177 antibodyAnti-Protein Evenness Interrupted Homolog antibodyAnti-Evi antibodyAnti-Putative Nf-Kappa-B-Activating Protein 373 antibodyAnti-WLS antibodyAnti-C1orf139 antibodyAnti-GPR177 antibodyAnti-UNQ85 antibodyAnti-PRO18667 antibody |
Information sourced from Uniprot.org
