| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-WHIP/WRNIP1 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 90kDa band observed in lysates of cell line Jurkat (calculated MW of 72.1kDa according to NP_064520.2). The observed molecular weight corresponds to earlier findings in literatu |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | WRNIP1 |
| Gene ID: | 56897 |
| Uniprot ID: | WRIP1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_064520.2; NP_569079.1 |
| Specificity: | This antibody is expected to recognise isoform 1 (NP_064520.2) and isoform 2 (NP_569079.1). |
| Immunogen Sequence: | EELRGVDFFKQRRC |
| Post Translational Modifications | Sumoylated with SUMO1 and SUMO2/3. |
| Function | Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS. |
| Protein Name | Atpase Wrnip1Werner Helicase-Interacting Protein 1 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Wrn In Granular Structures In The Nucleus |
| Alternative Antibody Names | Anti-Atpase Wrnip1 antibodyAnti-Werner Helicase-Interacting Protein 1 antibodyAnti-WRNIP1 antibodyAnti-WHIP antibody |
Information sourced from Uniprot.org