| Function | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation.when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. |
| Protein Name | Wasp Homolog-Associated Protein With Actin - Membranes And MicrotubulesWas Protein Homology Region 2 Domain-Containing Protein 1Wh2 Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-9013405 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic Vesicle MembraneGolgi ApparatusCis-Golgi NetworkLocalized To A Perinuclear Compartment Near The Microtubule-Organizing Center (Mtoc)Also Detected On Tubulo-Vesicular Structures In The Cell Periphery That Frequently Localized Along Microtubules |
| Alternative Antibody Names | Anti-Wasp Homolog-Associated Protein With Actin - Membranes And Microtubules antibodyAnti-Was Protein Homology Region 2 Domain-Containing Protein 1 antibodyAnti-Wh2 Domain-Containing Protein 1 antibodyAnti-WHAMM antibodyAnti-KIAA1971 antibodyAnti-WHDC1 antibody |
Information sourced from Uniprot.org
