| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WASP homolog-associated protein with actin, membranes and microtubules (387-437 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WHAMM |
| Gene ID: |
123720 |
| Uniprot ID: |
WHAMM_HUMAN |
| Immunogen Region: |
387-437 aa |
| Specificity: |
This antibody detects endogenous levels of human WHAMM |
| Immunogen: |
Synthesized peptide derived from the human WHAMM at the amino acid range 387-437 |
| Function | Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation.when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. |
| Protein Name | Wasp Homolog-Associated Protein With Actin - Membranes And MicrotubulesWas Protein Homology Region 2 Domain-Containing Protein 1Wh2 Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-9013405 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum-Golgi Intermediate CompartmentCytoplasmic Vesicle MembraneGolgi ApparatusCis-Golgi NetworkLocalized To A Perinuclear Compartment Near The Microtubule-Organizing Center (Mtoc)Also Detected On Tubulo-Vesicular Structures In The Cell Periphery That Frequently Localized Along Microtubules |
| Alternative Antibody Names | Anti-Wasp Homolog-Associated Protein With Actin - Membranes And Microtubules antibodyAnti-Was Protein Homology Region 2 Domain-Containing Protein 1 antibodyAnti-Wh2 Domain-Containing Protein 1 antibodyAnti-WHAMM antibodyAnti-KIAA1971 antibodyAnti-WHDC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
