| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Wee1-like protein kinase 2 (151-200 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WEE2 |
| Gene ID: | 494551 |
| Uniprot ID: | WEE2_HUMAN |
| Immunogen Region: | 151-200 aa |
| Specificity: | Wee 2 Polyclonal Antibody detects endogenous levels of Wee 2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human WEE2 at the amino acid range 151-200 |
| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylation leads to increase its activity. |
| Function | Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. |
| Protein Name | Wee1-Like Protein Kinase 2Wee1-Like Protein Kinase 1bWee1b Kinase |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wee1-Like Protein Kinase 2 antibodyAnti-Wee1-Like Protein Kinase 1b antibodyAnti-Wee1b Kinase antibodyAnti-WEE2 antibodyAnti-WEE1B antibody |
Information sourced from Uniprot.org