| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WDR5 |
| Gene ID: | 11091 |
| Uniprot ID: | WDR5_HUMAN |
| Immunogen Region: | 235-334 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 235-334 of human WDR5 (NP_060058.1). |
| Immunogen Sequence: | DNTLKLWDYSKGKCLKTYTG HKNEKYCIFANFSVTGGKWI VSGSEDNLVYIWNLQTKEIV QKLQGHTDVVISTACHPTEN IIASAALENDKTIKLWKSDC |
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Wd Repeat-Containing Protein 5 Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841 Reactome: R-HSA-3214847 Reactome: R-HSA-3214858 Reactome: R-HSA-5617472 Reactome: R-HSA-8936459 Reactome: R-HSA-8951664 Reactome: R-HSA-9733709 Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 5 antibody Anti-Bmp2-Induced 3-Kb Gene Protein antibody Anti-WDR5 antibody Anti-BIG3 antibody |
Information sourced from Uniprot.org