Anti-WDR5 antibody (157-174) (STJ503518)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide: DVKTGKCLKTLPAHSDPV corresponding to amino acids 157-174 of Human WDR5 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-WDR5 (157-174) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | A.thaliana/Bovine/Chicken/Dog/Human/Monkey/Mouse/Pig/Rat/Xenopus/Zebra Fish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.67 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:100 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR5 |
| Gene ID | 11091 |
| Uniprot ID | WDR5_HUMAN |
| Immunogen | Synthetic peptide: DVKTGKCLKTLPAHSDPV corresponding to amino acids 157-174 of Human WDR5 protein. |
| Immunogen Region | 157-174 |
Additional Info
| Function | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
| Protein Name | Wd Repeat-Containing Protein 5Bmp2-Induced 3-Kb Gene Protein |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9733709Reactome: R-HSA-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 5 antibodyAnti-Bmp2-Induced 3-Kb Gene Protein antibodyAnti-WDR5 antibodyAnti-BIG3 antibody |
Information sourced from Uniprot.org