| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WD repeat domain phosphoinositide-interacting protein 4 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WDR45 |
| Gene ID: |
11152 |
| Uniprot ID: |
WIPI4_HUMAN |
| Specificity: |
This antibody detects endogenous levels of WDR45 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human WDR45 |
| Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. |
| Protein Name | Wd Repeat Domain Phosphoinositide-Interacting Protein 4Wipi-4Wd Repeat-Containing Protein 45 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | Preautophagosomal StructureCytoplasmDiffusely Localized In The Cytoplasm Under Nutrient-Rich ConditionsLocalizes To Autophagic Structures During Starvation-Induced Autophagy |
| Alternative Antibody Names | Anti-Wd Repeat Domain Phosphoinositide-Interacting Protein 4 antibodyAnti-Wipi-4 antibodyAnti-Wd Repeat-Containing Protein 45 antibodyAnti-WDR45 antibodyAnti-WDRX1 antibodyAnti-WDRXI4 antibodyAnti-WIPI4 antibodyAnti-JM5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
