| Tissue Specificity | Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors. |
| Function | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. |
| Protein Name | Wd Repeat Domain Phosphoinositide-Interacting Protein 4Wipi-4Wd Repeat-Containing Protein 45 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | Preautophagosomal StructureCytoplasmDiffusely Localized In The Cytoplasm Under Nutrient-Rich ConditionsLocalizes To Autophagic Structures During Starvation-Induced Autophagy |
| Alternative Antibody Names | Anti-Wd Repeat Domain Phosphoinositide-Interacting Protein 4 antibodyAnti-Wipi-4 antibodyAnti-Wd Repeat-Containing Protein 45 antibodyAnti-WDR45 antibodyAnti-WDRX1 antibodyAnti-WDRXI4 antibodyAnti-WIPI4 antibodyAnti-JM5 antibody |
Information sourced from Uniprot.org
