Anti-WDR11 antibody (975-1224) (STJ112603)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal WDR11 (975-1224) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | WDR11 |
| Gene ID | 55717 |
| Uniprot ID | WDR11_HUMAN |
| Immunogen Region | 975-1224 |
| Immunogen Sequence | YFQKFQLERVNLQEVKRSTY DHTRKCTDQLLLLGQTDRAV QLLLETSADNQHYYCDSLKA CLVTTVTSSGPSQSTIKLVA TNMIANGKLAEGVQLLCLID KAADACRYLQTYGEWNRAAW LAKVRLNPEECADVLRRWVD HLCSPQVNQKSKALLVLLSL GCFFSVAETLHSMRYFDRAA LFVEACLKYGAFEVTEDTEK LITAIYADYARSLKNLGFKQ GAVLFASKAGAAGKDLLNE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 975-1224 of human WDR11 (NP_060587.8). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1. |
| Protein Name | Wd Repeat-Containing Protein 11Bromodomain And Wd Repeat-Containing Protein 2Wd Repeat-Containing Protein 15 |
| Database Links | Reactome: R-HSA-9013407 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyNucleusCilium AxonemeCytoplasmic VesicleGolgi ApparatusTrans-Golgi NetworkShuttles From The Cilium To The Nucleus In Response To Hh SignalingMight Be Shuttling Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Wd Repeat-Containing Protein 11 antibodyAnti-Bromodomain And Wd Repeat-Containing Protein 2 antibodyAnti-Wd Repeat-Containing Protein 15 antibodyAnti-WDR11 antibodyAnti-BRWD2 antibodyAnti-KIAA1351 antibodyAnti-WDR15 antibody |
Information sourced from Uniprot.org