| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | WDFY4 |
| Gene ID: | 57705 |
| Uniprot ID: | WDFY4_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human WDFY4 (NP_065996.1). |
| Immunogen Sequence: | MEAEDLSKAEDRNEDPGSKN EGQLAAVQPDVPHGGQSSSP TALWDMLERKFLEYQQLTHK SPIERQKSLLSLLPLFLKAW EHSVGIICFPSLQRLAEDVS DQLAQQLQKALVGKPAEQAR LAAGQLLWWKGDVDQDGYLL LKSVYVLTGTDSETLGRVAE |
| Function | Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy. |
| Protein Name | Wd Repeat- And Fyve Domain-Containing Protein 4 |
| Cellular Localisation | Early EndosomeEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Wd Repeat- And Fyve Domain-Containing Protein 4 antibodyAnti-WDFY4 antibodyAnti-C10orf64 antibodyAnti-KIAA1607 antibody |
Information sourced from Uniprot.org