| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation (33-194) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VSIR |
| Gene ID: |
64115 |
| Uniprot ID: |
VISTA_HUMAN |
| Immunogen Region: |
33-194 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 33-194 of human VISTA/B7-H5/GI24 (NP_071436.1). |
| Immunogen Sequence: |
FKVATPYSLYVCPEGQNVTL TCRLLGPVDKGHDVTFYKTW YRSSRGEVQTCSERRPIRNL TFQDLHLHHGGHQAANTSHD LAQRHGLESASDHHGNFSIT MRNLTLLDSGLYCCLVVEIR HHHSEHRVHGAMELQVQTGK DAPSNCVVYPSSSQDSENIT AA |
| Tissue Specificity | Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues. |
| Post Translational Modifications | At the cell surface, may be cleaved by MMP14. N-glycosylated. |
| Function | Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. |
| Protein Name | V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell ActivationPlatelet Receptor Gi24Stress-Induced Secreted Protein-1Sisp-1V-Set Domain-Containing Immunoregulatory ReceptorV-Set Immunoregulatory Receptor |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation antibodyAnti-Platelet Receptor Gi24 antibodyAnti-Stress-Induced Secreted Protein-1 antibodyAnti-Sisp-1 antibodyAnti-V-Set Domain-Containing Immunoregulatory Receptor antibodyAnti-V-Set Immunoregulatory Receptor antibodyAnti-VSIR antibodyAnti-C10orf54 antibodyAnti-SISP1 antibodyAnti-VISTA antibodyAnti-PP2135 antibodyAnti-UNQ730 antibodyAnti-PRO1412 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
