Anti-VPS41 antibody [R08-1J7] (STJA0035001)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human VPS41
General Information
| Short Description | Rabbit monoclonal anti-VPS41 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-1J7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | VPS41 |
| Gene ID | 27072 |
| Uniprot ID | VPS41_HUMAN |
| Immunogen | A synthetic peptide of human VPS41 |
Additional Info
| Tissue Specificity | Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells. |
| Function | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo. Required for fusion of autophagosomes with lysosomes. Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion. Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS. Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex. May play a role in HOPS-independent function in the regulated secretory pathway. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 41 HomologS53 |
| Database Links | Reactome: R-HSA-9754560 |
| Cellular Localisation | Endosome MembranePeripheral Membrane ProteinLate Endosome MembraneEarly Endosome MembraneLysosome MembraneGolgi ApparatusTrans-Golgi NetworkCytoplasmic VesicleClathrin-Coated VesicleCytoplasmCytosol(Microbial Infection) Sequestrated At The Late Endosome By Sars Coronavirus-2/Sars-Cov-2 Orf3a Protein |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 41 Homolog antibodyAnti-S53 antibodyAnti-VPS41 antibody |
Information sourced from Uniprot.org