Anti-VPS36 antibody (250-310) {FITC} (STJ503505)

SKU:
STJ503505-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-VPS36 (250-310) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: VPS36
Gene ID: 51028
Uniprot ID: VPS36_HUMAN
Immunogen Region: 250-310
Immunogen: Synthetic peptide taken within amino acid region 250-310 on human Vacuolar Protein-Sorting-associated protein 36 protein.
Function Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Protein Name Vacuolar Protein-Sorting-Associated Protein 36
Ell-Associated Protein Of 45 Kda
Escrt-Ii Complex Subunit Vps36
Database Links Reactome: R-HSA-917729
Reactome: R-HSA-9610379
Cellular Localisation Cytoplasm
Endosome
Late Endosome
Membrane
Nucleus
Colocalizes With Ubiquitinated Proteins On Late Endosomes
Recruited To The Endosome Membrane To Participate In Vesicle Formation
Alternative Antibody Names Anti-Vacuolar Protein-Sorting-Associated Protein 36 antibody
Anti-Ell-Associated Protein Of 45 Kda antibody
Anti-Escrt-Ii Complex Subunit Vps36 antibody
Anti-VPS36 antibody
Anti-C13orf9 antibody
Anti-EAP45 antibody
Anti-CGI-145 antibody

Information sourced from Uniprot.org

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