| Function | Acts as a component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 26cDown Syndrome Critical Region Protein 3Down Syndrome Critical Region Protein A |
| Cellular Localisation | Endosome |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 26c antibodyAnti-Down Syndrome Critical Region Protein 3 antibodyAnti-Down Syndrome Critical Region Protein A antibodyAnti-VPS26C antibodyAnti-DCRA antibodyAnti-DSCR3 antibodyAnti-DSCRA antibody |
Information sourced from Uniprot.org
