| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Vacuolar protein sorting-associated protein 26C (163-213 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VPS26C |
| Gene ID: |
10311 |
| Uniprot ID: |
VP26C_HUMAN |
| Immunogen Region: |
163-213 aa |
| Specificity: |
This antibody detects endogenous levels of DSCR3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human DSCR3 at the amino acid range 163-213 |
| Function | Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface. |
| Protein Name | Vacuolar Protein Sorting-Associated Protein 26cDown Syndrome Critical Region Protein 3Down Syndrome Critical Region Protein A |
| Cellular Localisation | Endosome |
| Alternative Antibody Names | Anti-Vacuolar Protein Sorting-Associated Protein 26c antibodyAnti-Down Syndrome Critical Region Protein 3 antibodyAnti-Down Syndrome Critical Region Protein A antibodyAnti-VPS26C antibodyAnti-DCRA antibodyAnti-DSCR3 antibodyAnti-DSCRA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
