| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VPS13A |
| Gene ID: |
23230 |
| Uniprot ID: |
VP13A_HUMAN |
| Immunogen Region: |
350-600 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human VPS13A (NP_150648.2). |
| Immunogen Sequence: |
WSWKHIRKHRQKVKQYKELY KKKLTSKKPPGELLVSLEEL EKTLDVFNITIARQTAEVEV KKAGYKIYKEGVKDPEDNKG WFSWLWSWSEQNTNEQQPDV QPETLEEMLTPEEKALLYEA IGYSETAVDPTLLKTFEALK FFVHLKSMSIVLRENHQKPE LVDIVIEEFSTLIVQRPGAQ AIKFETKIDSFHITGLPDNS EKPRLLSSLDDAMSLFQITF EINPLDETVSQRCIIEAEP |
| Tissue Specificity | Expressed in red blood cells (at protein level). Widely expressed, with high expression in brain, heart, skeletal muscle and kidney. |
| Function | Mediates the transfer of lipids between membranes at organelle contact sites. Binds phospholipids. Required for the formation or stabilization of ER-mitochondria contact sites which enable transfer of lipids between the ER and mitochondria. Negatively regulates lipid droplet size and motility. Required for efficient lysosomal protein degradation. |
| Protein Name | Intermembrane Lipid Transfer Protein Vps13aChorea-Acanthocytosis ProteinChoreinVacuolar Protein Sorting-Associated Protein 13a |
| Cellular Localisation | Mitochondrion Outer MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneEndosome MembraneLysosome MembraneLipid DropletGolgi ApparatusCytoplasmic VesicleSecretory VesicleNeuronal Dense Core VesicleLocalizes At Mitochondria-Endosomes And Mitochondria-Endoplasmic Reticulum Contact Sites |
| Alternative Antibody Names | Anti-Intermembrane Lipid Transfer Protein Vps13a antibodyAnti-Chorea-Acanthocytosis Protein antibodyAnti-Chorein antibodyAnti-Vacuolar Protein Sorting-Associated Protein 13a antibodyAnti-VPS13A antibodyAnti-CHAC antibodyAnti-KIAA0986 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
