| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-von Willebrand Factor is suitable for use in Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | 36B11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | Tissue culture supernatant with sodium azide |
| Concentration: | >=21 mg/L |
| Dilution Range: | IHC-P 1:200 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | VWF |
| Gene ID: | 7450 |
| Uniprot ID: | VWF_HUMAN |
| Immunogen: | Prokaryotic recombinant fusion protein corresponding to the A2 domain of the von Willebrand molecule. |
| Tissue Specificity | Plasma. |
| Post Translational Modifications | All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated. |
| Function | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| Protein Name | Von Willebrand FactorVwf Cleaved Into - Von Willebrand Antigen 2Von Willebrand Antigen Ii |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-216083Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-430116Reactome: R-HSA-5674135Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-75892Reactome: R-HSA-76009Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9672391Reactome: R-HSA-9672393 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixLocalized To Storage Granules |
| Alternative Antibody Names | Anti-Von Willebrand Factor antibodyAnti-Vwf Cleaved Into - Von Willebrand Antigen 2 antibodyAnti-Von Willebrand Antigen Ii antibodyAnti-VWF antibodyAnti-F8VWF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
