| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VIRMA |
| Gene ID: | 25962 |
| Uniprot ID: | VIR_HUMAN |
| Immunogen Region: | 1400-1700 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1700 of human KIAA1429 (NP_056311.2). |
| Immunogen Sequence: | FMRQILNSDTIGCCGDDNGL MEVEGAHTSRTMSINAAELK QLLQSKEESPENLFLELEKL VLEHSKDDDNLDSLLDSVVG LKQMLESSGDPLPLSDQDVE PVLSAPESLQNLFNNRTAYV LADVMDDQLKSMWFTPFQAE EIDTDLDLVKVDLIELSEKC CSDFDLHSELERSFLSEPSS PGRTKTTKGFKLGKHKHETF ITSSGKSEYIEPAKRAHVVP PPRGRGRGGFGQGIRPHDI |
| Function | Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon correlating with alternative polyadenylation (APA). |
| Protein Name | Protein Virilizer Homolog |
| Cellular Localisation | Nucleus SpeckleNucleusNucleoplasmCytoplasmMainly Nuclear With Some Fraction Located In The CytoplasmZc3h13 Is Required To Anchor Component Of The Macom SubcomplexSuch As VirmaIn The Nucleus |
| Alternative Antibody Names | Anti-Protein Virilizer Homolog antibodyAnti-VIRMA antibodyAnti-KIAA1429 antibodyAnti-MSTP054 antibody |
Information sourced from Uniprot.org
