| Function | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. |
| Protein Name | Vasoactive Intestinal Polypeptide Receptor 1Vip-R-1Pituitary Adenylate Cyclase-Activating Polypeptide Type Ii ReceptorPacap Type Ii ReceptorPacap-R-2Pacap-R2Vpac1 ReceptorVpac1r |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vasoactive Intestinal Polypeptide Receptor 1 antibodyAnti-Vip-R-1 antibodyAnti-Pituitary Adenylate Cyclase-Activating Polypeptide Type Ii Receptor antibodyAnti-Pacap Type Ii Receptor antibodyAnti-Pacap-R-2 antibodyAnti-Pacap-R2 antibodyAnti-Vpac1 Receptor antibodyAnti-Vpac1r antibodyAnti-VIPR1 antibody |
Information sourced from Uniprot.org