Anti-VIPR1 antibody (31-150) (STJ116410)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VIPR1 (31-150) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VIPR1 |
| Gene ID | 7433 |
| Uniprot ID | VIPR1_HUMAN |
| Immunogen Region | 31-150 |
| Immunogen Sequence | ARLQEECDYVQMIEVQHKQC LEEAQLENETIGCSKMWDNL TCWPATPRGQVVVLACPLIF KLFSSIQGRNVSRSCTDEGW THLEPGPYPIACGLDDKAAS LDEQQTMFYGSVKTGYTIGY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 31-150 of human VIPR1 (NP_004615.2). |
Additional Info
| Tissue Specificity | In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT. |
| Function | G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. |
| Protein Name | Vasoactive Intestinal Polypeptide Receptor 1Vip-R-1Pituitary Adenylate Cyclase-Activating Polypeptide Type Ii ReceptorPacap Type Ii ReceptorPacap-R-2Pacap-R2Vpac1 ReceptorVpac1r |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vasoactive Intestinal Polypeptide Receptor 1 antibodyAnti-Vip-R-1 antibodyAnti-Pituitary Adenylate Cyclase-Activating Polypeptide Type Ii Receptor antibodyAnti-Pacap Type Ii Receptor antibodyAnti-Pacap-R-2 antibodyAnti-Pacap-R2 antibodyAnti-Vpac1 Receptor antibodyAnti-Vpac1r antibodyAnti-VIPR1 antibody |
Information sourced from Uniprot.org