Anti-VIP antibody (31-170 aa) [SRM5438] (STJ11107351)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal VIP (31-170 aa) antibody for use in IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5438 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VIP |
| Gene ID | 7432 |
| Uniprot ID | VIP_HUMAN |
| Immunogen Region | 31-170 aa |
| Immunogen Sequence | APSALRLGDRIPFEGANEPD QVSLKEDIDMLQNALAENDT PYYDVSRNARHADGVFTSDF SKLLGQLSAKKYLESLMGKR VSSNISEDPVPVKRHSDAVF TDNYTRLRKQMAVKKYLNSI LNGKRSSEGESPDFPEELEK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 31-170 of human VIP (NP_003372.1). |
Additional Info
| Function | Vasoactive intestinal peptide: VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. PHM-27 and PHV-42 are two bioactive forms from proteolysis of the same precursor protein, that cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. |
| Protein Name | Vip Peptides Cleaved Into - Intestinal Peptide Phv-42Peptide Histidine Valine 42Phv-42 - Intestinal Peptide Phm-27Peptide Histidine Methioninamide 27Phm-27 - Vasoactive Intestinal PeptideVipVasoactive Intestinal Polypeptide |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Vip Peptides Cleaved Into - Intestinal Peptide Phv-42 antibodyAnti-Peptide Histidine Valine 42 antibodyAnti-Phv-42 - Intestinal Peptide Phm-27 antibodyAnti-Peptide Histidine Methioninamide 27 antibodyAnti-Phm-27 - Vasoactive Intestinal Peptide antibodyAnti-Vip antibodyAnti-Vasoactive Intestinal Polypeptide antibodyAnti-VIP antibody |
Information sourced from Uniprot.org