| Function | Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, sodium and phosphate. At the synaptic vesicle membrane, mainly functions as an uniporter that mediates the uptake of L-glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. The L-glutamate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane. In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification. At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation. The symporter activity is electrogenic. Moreover, operates synergistically with SLC18A3/VACHT under a constant H(+) gradient, thereby allowing striatal vesicular acetylcholine uptake. |
| Protein Name | Vesicular Glutamate Transporter 3Vglut3Solute Carrier Family 17 Member 8 |
| Database Links | Reactome: R-MMU-428643 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneCell MembraneMulti-Pass Membrane ProteinSynapseSynaptosome |
| Alternative Antibody Names | Anti-Vesicular Glutamate Transporter 3 antibodyAnti-Vglut3 antibodyAnti-Solute Carrier Family 17 Member 8 antibodyAnti-Slc17a8 antibodyAnti-Vglut3 antibody |
Information sourced from Uniprot.org
