| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-Dependent Anion-Selective Channel Protein 2 (1-309) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VDAC2 |
| Gene ID: |
7417 |
| Uniprot ID: |
VDAC2_HUMAN |
| Immunogen Region: |
1-309 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human VDAC2 (NP_001171712.1). |
| Immunogen Sequence: |
MSWCNELRLPALKQHSIGRG LESHITMCIPPSYADLGKAA RDIFNKGFGFGLVKLDVKTK SCSGVEFSTSGSSNTDTGKV TGTLETKYKWCEYGLTFTEK WNTDNTLGTEIAIEDQICQG LKLTFDTTFSPNTGKKSGKI KSSYKRECINLGCDVDFDFA GPAIHGSAVFGYEGWLAGYQ MTFDSAKSKLTRNNFAVGYR TGDFQLHTNVNDGTEFGGSI YQKVCEDLDTSVNLAWTSG |
| Tissue Specificity | Expressed in erythrocytes (at protein level). Expressed in all tissues examined. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway. |
| Protein Name | Voltage-Dependent Anion-Selective Channel Protein 2Vdac-2Hvdac2Outer Mitochondrial Membrane Protein Porin 2 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Voltage-Dependent Anion-Selective Channel Protein 2 antibodyAnti-Vdac-2 antibodyAnti-Hvdac2 antibodyAnti-Outer Mitochondrial Membrane Protein Porin 2 antibodyAnti-VDAC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
