Anti-VCPIP1 antibody (STJA0008148)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human VCPIP1
General Information
| Short Description | Rabbit polyclonal anti-Deubiquitinating protein VCPIP1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VCPIP1 |
| Gene ID | 80124 |
| Uniprot ID | VCIP1_HUMAN |
| Immunogen | Synthesized peptide derived from human VCPIP1 |
| Specificity | This antibody detects endogenous levels of VCPIP1 at Human, Mouse, Rat |
Additional Info
| Function | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. |
| Protein Name | Deubiquitinating Protein Vcpip1Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135Vcp/P47 Complex-Interacting 135-Kda Protein |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumGolgi ApparatusGolgi StackAssociated With Golgi Stacks And Endoplasmic ReticulumDisplays Cytoplasmic To Nuclear Translocation In Response To Dna-Protein Cross-Links (Dpcs)-Inducing Agents |
| Alternative Antibody Names | Anti-Deubiquitinating Protein Vcpip1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 antibodyAnti-Vcp/P47 Complex-Interacting 135-Kda Protein antibodyAnti-VCPIP1 antibodyAnti-KIAA1850 antibodyAnti-VCIP135 antibody |
Information sourced from Uniprot.org