| Function | Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains. (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients. |
| Protein Name | Deubiquitinating Protein Vcpip1Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135Vcp/P47 Complex-Interacting 135-Kda Protein |
| Database Links | Reactome: R-HSA-5689896 |
| Cellular Localisation | NucleusCytoplasmEndoplasmic ReticulumGolgi ApparatusGolgi StackAssociated With Golgi Stacks And Endoplasmic ReticulumDisplays Cytoplasmic To Nuclear Translocation In Response To Dna-Protein Cross-Links (Dpcs)-Inducing Agents |
| Alternative Antibody Names | Anti-Deubiquitinating Protein Vcpip1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein 1 antibodyAnti-Valosin-Containing Protein P97/P47 Complex-Interacting Protein P135 antibodyAnti-Vcp/P47 Complex-Interacting 135-Kda Protein antibodyAnti-VCPIP1 antibodyAnti-KIAA1850 antibodyAnti-VCIP135 antibody |
Information sourced from Uniprot.org
