• Western blot analysis of lysates from wild type (WT) and VAV2 knockout (KO) HeLa cells, using [KO Validated] VAV2 Rabbit polyclonal antibody (STJ11100759) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-VAV2 antibody (570-700) (STJ11100759)

SKU:
STJ11100759

£129.50 - £639.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-VAV2 (570-700) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VAV2
Gene ID: 7410
Uniprot ID: VAV2_HUMAN
Immunogen Region: 570-700
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 570-700 of human VAV2 (NP_001127870.1).
Immunogen Sequence: PPCKFTSPADLDASGAGPGP KMVAMQNYHGNPAPPGKPVL TFQTGDVLELLRGDPESPWW EGRLVQTRKSGYFPSSSVKP CPVDGRPPISRPPSREIDYT AYPWFAGNMERQQTDNLLKS HASGTYLIRER
Tissue Specificity Widely expressed.
Post Translational Modifications Phosphorylated on tyrosine residues in response to FGR activation.
Function Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Protein Name Guanine Nucleotide Exchange Factor Vav2
Vav-2
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-193648
Reactome: R-HSA-2029482
Reactome: R-HSA-2424491
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-3928665
Reactome: R-HSA-416482
Reactome: R-HSA-4420097
Reactome: R-HSA-445144
Reactome: R-HSA-5218920
Reactome: R-HSA-8980692
Reactome: R-HSA-9013026
Reactome: R-HSA-9013106
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013404
Reactome: R-HSA-9013408
Reactome: R-HSA-9013423
Reactome: R-HSA-9664422
Reactome: R-HSA-9748787
Alternative Antibody Names Anti-Guanine Nucleotide Exchange Factor Vav2 antibody
Anti-Vav-2 antibody
Anti-VAV2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance