| Host: | Rabbit |
| Applications: | IHC-F/WB |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Vanilloid receptor-like protein 1 (aa: 744-761) for use in IHC-F and WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilized from PBS, pH 7.4, containing 0.02% sodium azide as preservative. |
| Purification: | Affinity-purified |
| Dilution Range: | WB 0.5-1 µg/mLIHC 0.5-1 µg/mLICC 0.5-1 µg/mL |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | Trpv2 |
| Gene ID: | 29465 |
| Uniprot ID: | TRPV2_RAT |
| Immunogen Region: | aa: 744-761 |
| Specificity: | Immunohistochemical analysis in rat dorsal root ganglia and spinal cord indicates a high level of specificity for this antiserum. Specificity was also shown by Western blot. This antibody is known to react with rat and human VRL-1. |
| Immunogen: | A synthetic peptide (C-KNSASEEDHLPLQVLQSP) as part of rat VRL-1 protein (aa: 744-761) conjugated to KLH has been used as the immunogen. |
| Immunogen Sequence: | Rat |
| Tissue Specificity | Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal cord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). |
| Post Translational Modifications | N-glycosylated. Phosphorylated by PKA. |
| Function | Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius.is not activated by vanilloids and acidic pH. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 2Trpv2Osm-9-Like Trp Channel 2Otrpc2Stretch-Activated Channel 2bVanilloid Receptor-Like Protein 1Vrl-1 |
| Database Links | Reactome: R-RNO-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmMelanosomeTranslocates From The Cytoplasm To The Plasma Membrane Upon Ligand Stimulation |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 2 antibodyAnti-Trpv2 antibodyAnti-Osm-9-Like Trp Channel 2 antibodyAnti-Otrpc2 antibodyAnti-Stretch-Activated Channel 2b antibodyAnti-Vanilloid Receptor-Like Protein 1 antibodyAnti-Vrl-1 antibodyAnti-Trpv2 antibodyAnti-Sac2b antibodyAnti-Vrl1 antibody |
Information sourced from Uniprot.org
