Host: |
Rabbit |
Applications: |
IHC/WB |
Reactivity: |
Human/Mouse/Rat/Marmoset |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-VACHT is suitable for use in Immunohistochemistry and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Lyophilised |
Purification: |
IgG purified |
Dilution Range: |
IHC, WB. A dilution of 1: 2000 is recommended for WB and to 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Gene Symbol: |
SLC18A3 |
Gene ID: |
6572 |
Uniprot ID: |
VACHT_HUMAN |
Specificity: |
Specific for VACHT. |
Immunogen: |
A synthetic peptide from human VACHT conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse. |
Function | Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin. |
Protein Name | Vesicular Acetylcholine TransporterVachtSolute Carrier Family 18 Member 3 |
Database Links | Reactome: R-HSA-264642Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Vesicular Acetylcholine Transporter antibodyAnti-Vacht antibodyAnti-Solute Carrier Family 18 Member 3 antibodyAnti-SLC18A3 antibodyAnti-VACHT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance