Anti-VACHT antibody (STJ13100453)

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STJ13100453-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat/Marmoset
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-VACHT is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1: 2000 is recommended for WB and to 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SLC18A3
Gene ID: 6572
Uniprot ID: VACHT_HUMAN
Specificity: Specific for VACHT.
Immunogen: A synthetic peptide from human VACHT conjugated to blue carrier protein was used as the antigen. The antigen is homologous in rat and mouse.
Function Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin.
Protein Name Vesicular Acetylcholine Transporter
Vacht
Solute Carrier Family 18 Member 3
Database Links Reactome: R-HSA-264642
Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Vesicular Acetylcholine Transporter antibody
Anti-Vacht antibody
Anti-Solute Carrier Family 18 Member 3 antibody
Anti-SLC18A3 antibody
Anti-VACHT antibody

Information sourced from Uniprot.org

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