| Function | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. |
| Protein Name | Protein Vac14 HomologTax1-Binding Protein 2 |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome MembraneMicrosome MembraneMainly Associated With Membranes Of The Late Endocytic Pathway |
| Alternative Antibody Names | Anti-Protein Vac14 Homolog antibodyAnti-Tax1-Binding Protein 2 antibodyAnti-VAC14 antibodyAnti-TAX1BP2 antibodyAnti-TRX antibody |
Information sourced from Uniprot.org
