| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein VAC14 homolog (569-619 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VAC14 |
| Gene ID: | 55697 |
| Uniprot ID: | VAC14_HUMAN |
| Immunogen Region: | 569-619 aa |
| Specificity: | This antibody detects endogenous levels of human VAC14 |
| Immunogen: | Synthesized peptide derived from the human VAC14 at the amino acid range 569-619 |
| Function | Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. |
| Protein Name | Protein Vac14 Homolog Tax1-Binding Protein 2 |
| Database Links | Reactome: R-HSA-1660514 Reactome: R-HSA-1660516 Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome Membrane Microsome Membrane Mainly Associated With Membranes Of The Late Endocytic Pathway |
| Alternative Antibody Names | Anti-Protein Vac14 Homolog antibody Anti-Tax1-Binding Protein 2 antibody Anti-VAC14 antibody Anti-TAX1BP2 antibody Anti-TRX antibody |
Information sourced from Uniprot.org