Anti-VAC14 antibody (569-619 aa) (STJ198053)

SKU:
STJ198053
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Protein VAC14 homolog (569-619 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VAC14
Gene ID: 55697
Uniprot ID: VAC14_HUMAN
Immunogen Region: 569-619 aa
Specificity: This antibody detects endogenous levels of human VAC14
Immunogen: Synthesized peptide derived from the human VAC14 at the amino acid range 569-619
Function Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Protein Name Protein Vac14 Homolog
Tax1-Binding Protein 2
Database Links Reactome: R-HSA-1660514
Reactome: R-HSA-1660516
Reactome: R-HSA-1660517
Cellular Localisation Endosome Membrane
Microsome Membrane
Mainly Associated With Membranes Of The Late Endocytic Pathway
Alternative Antibody Names Anti-Protein Vac14 Homolog antibody
Anti-Tax1-Binding Protein 2 antibody
Anti-VAC14 antibody
Anti-TAX1BP2 antibody
Anti-TRX antibody

Information sourced from Uniprot.org

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