| Post Translational Modifications | Phosphorylated. Phosphorylation is required to promote p53/TP53 degradation in the nucleolus which promotes cell cycle progression and liver development. |
| Function | Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing. Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development. Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53. |
| Protein Name | U3 Small Nucleolar Rna-Associated Protein 25 HomologDigestive Organ Expansion Factor HomologUtp25 Small Subunit Processor Component |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Rna-Associated Protein 25 Homolog antibodyAnti-Digestive Organ Expansion Factor Homolog antibodyAnti-Utp25 Small Subunit Processor Component antibodyAnti-UTP25 antibodyAnti-C1orf107 antibodyAnti-DEF antibodyAnti-DIEXF antibody |
Information sourced from Uniprot.org
