Anti-USP50 antibody (251-300 aa) (STJ96209)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human USP50 at the amino acid range 251-300
General Information
| Short Description | Rabbit polyclonal anti-Inactive ubiquitin carboxyl-terminal hydrolase 50 (251-300 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP50 |
| Gene ID | 373509 |
| Uniprot ID | UBP50_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human USP50 at the amino acid range 251-300 |
| Immunogen Region | 251-300 aa |
| Specificity | USP50 Polyclonal Antibody detects endogenous levels of USP50 protein. |
Additional Info
| Function | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 50Ubiquitin-Specific Peptidase 50 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusAccumulates In The Nucleus Following Dna Injury |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 50 antibodyAnti-Ubiquitin-Specific Peptidase 50 antibodyAnti-USP50 antibody |
Information sourced from Uniprot.org