| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Inactive ubiquitin carboxyl-terminal hydrolase 50 (251-300 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | USP50 |
| Gene ID: | 373509 |
| Uniprot ID: | UBP50_HUMAN |
| Immunogen Region: | 251-300 aa |
| Specificity: | USP50 Polyclonal Antibody detects endogenous levels of USP50 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human USP50 at the amino acid range 251-300 |
| Function | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 50Ubiquitin-Specific Peptidase 50 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusAccumulates In The Nucleus Following Dna Injury |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 50 antibodyAnti-Ubiquitin-Specific Peptidase 50 antibodyAnti-USP50 antibody |
Information sourced from Uniprot.org