• Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using USP48 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-USP48 antibody (631-680 aa) (STJ96208)

SKU:
STJ96208

Current Stock:
Host: Rabbit
Applications: IHC/IF/WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ubiquitin carboxyl-terminal hydrolase 48 (631-680 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:5000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: USP48
Gene ID: 84196
Uniprot ID: UBP48_HUMAN
Immunogen Region: 631-680 aa
Specificity: USP48 Polyclonal Antibody detects endogenous levels of USP48 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human USP48 at the amino acid range 631-680
Function Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H. pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Functions also in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination.
Protein Name Ubiquitin Carboxyl-Terminal Hydrolase 48
Deubiquitinating Enzyme 48
Ubiquitin Thioesterase 48
Ubiquitin-Specific Peptidase 48
Ubiquitin-Specific Protease 48
Ubiquitin-Specific-Processing Protease 48
Database Links Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Nucleus
Cell Projection
Cilium
Alternative Antibody Names Anti-Ubiquitin Carboxyl-Terminal Hydrolase 48 antibody
Anti-Deubiquitinating Enzyme 48 antibody
Anti-Ubiquitin Thioesterase 48 antibody
Anti-Ubiquitin-Specific Peptidase 48 antibody
Anti-Ubiquitin-Specific Protease 48 antibody
Anti-Ubiquitin-Specific-Processing Protease 48 antibody
Anti-USP48 antibody
Anti-USP31 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance