| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | USP46 |
| Gene ID: | 64854 |
| Uniprot ID: | UBP46_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human USP46 (NP_073743.2). |
| Immunogen Sequence: | KKFISRLRKENDLFDNYMQQ DAHEFLNYLLNTIADILQEE KKQEKQNGKLKNGNMNEPAE NNKPELTWVHEIFQGTLTNE TRCLNCETVSSKDEDFLDLS V |
| Tissue Specificity | Broadly expressed. |
| Function | Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 46Deubiquitinating Enzyme 46Ubiquitin Thioesterase 46Ubiquitin-Specific-Processing Protease 46 |
| Cellular Localisation | CytoplasmUsp46/Wdr48/Wdr20 Complex Is Predominantly Cytoplasmic |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 46 antibodyAnti-Deubiquitinating Enzyme 46 antibodyAnti-Ubiquitin Thioesterase 46 antibodyAnti-Ubiquitin-Specific-Processing Protease 46 antibodyAnti-USP46 antibody |
Information sourced from Uniprot.org