| Post Translational Modifications | Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis. Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment: Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus. |
| Function | Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 1Deubiquitinating Enzyme 1HubpUbiquitin Thioesterase 1Ubiquitin-Specific-Processing Protease 1 Cleaved Into - Ubiquitin Carboxyl-Terminal Hydrolase 1 - N-Terminal Fragment |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-6783310 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 1 antibodyAnti-Deubiquitinating Enzyme 1 antibodyAnti-Hubp antibodyAnti-Ubiquitin Thioesterase 1 antibodyAnti-Ubiquitin-Specific-Processing Protease 1 Cleaved Into - Ubiquitin Carboxyl-Terminal Hydrolase 1 - N-Terminal Fragment antibodyAnti-USP1 antibody |
Information sourced from Uniprot.org
