| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Usherin (3731-3781 aa) for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | USH2A |
| Gene ID: | 7399 |
| Uniprot ID: | USH2A_HUMAN |
| Immunogen Region: | 3731-3781 aa |
| Specificity: | This antibody detects endogenous levels of USH2A at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human USH2A at the amino acid range 3731-3781 |
| Function | Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. |
| Protein Name | UsherinUsher Syndrome Type Iia ProteinUsher Syndrome Type-2a Protein |
| Database Links | |
| Cellular Localisation | Cell ProjectionStereocilium MembraneSingle-Pass Type I Membrane ProteinComponent Of The Interstereocilia Ankle Links In The Inner Ear Sensory CellsIn PhotoreceptorsLocalizes At A Plasma Membrane Microdomain In The Apical Inner Segment That Surrounds The Connecting Cilia Called Periciliary Membrane ComplexIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Usherin antibodyAnti-Usher Syndrome Type Iia Protein antibodyAnti-Usher Syndrome Type-2a Protein antibodyAnti-USH2A antibody |
Information sourced from Uniprot.org
