| Tissue Specificity | Expressed in vestibule of the inner ear, eye and small intestine. |
| Function | Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs. May also participate in recycling of snRNPs back to Cajal bodies during splicing. Plays a role in regulating MAGI2-mediated endocytosis. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing. |
| Protein Name | Pre-Mrna Splicing Regulator Ush1gScaffold Protein Containing Ankyrin Repeats And Sam DomainUsher Syndrome Type-1g Protein |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | CytoplasmCytosolCytoskeletonCell MembranePeripheral Membrane ProteinCell ProjectionCiliumNucleus SpeckleNucleusCajal BodyMicrotubule Organizing CenterCentrosomePhotoreceptor Inner SegmentDetected At The Tip Of Cochlear Hair Cell StereociliaRecruited To The Cell Membrane Via Interaction With Cdh23 Or Pcdh15In Photoreceptor CiliaDetected Predominantly At The Cilium BaseExpressed In The Pericentriolar Region Of The Centrosome |
| Alternative Antibody Names | Anti-Pre-Mrna Splicing Regulator Ush1g antibodyAnti-Scaffold Protein Containing Ankyrin Repeats And Sam Domain antibodyAnti-Usher Syndrome Type-1g Protein antibodyAnti-USH1G antibodyAnti-SANS antibody |
Information sourced from Uniprot.org
