| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | USH1G |
| Gene ID: | 124590 |
| Uniprot ID: | USH1G_HUMAN |
| Immunogen Region: | 232-461 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 232-461 of human USH1G (NP_775748.2). |
| Immunogen Sequence: | KVSEDGRKSARSLSGLQLGS DVMFVRQGTYANPKEWGRAP LRDMFLSDEDSVSRATLAAE PAHSEVSTDSGHDSLFTRPG LGTMVFRRNYLSSGLHGLGR EDGGLDGVGAPRGRLQSSPS LDDDSLGSANSLQDRSCGEE LPWDELDLGLDEDLEPETSP LETFLASLHMEDFAALLRQE KIDLEALMLCSDLDLRSISV PLGPRKKILGAVRRRRQAME RPPALEDTEL |
| Tissue Specificity | Expressed in vestibule of the inner ear, eye and small intestine. |
| Function | Plays a role in pre-mRNA splicing by regulating the release and transfer of U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complexes from their assembly site in Cajal bodies to nuclear speckles, thereby contributing to the assembly of the pre-catalytic spliceosome on target pre-mRNAs. May also participate in recycling of snRNPs back to Cajal bodies during splicing. Plays a role in regulating MAGI2-mediated endocytosis. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. Required for normal hearing. |
| Protein Name | Pre-Mrna Splicing Regulator Ush1g Scaffold Protein Containing Ankyrin Repeats And Sam Domain Usher Syndrome Type-1g Protein |
| Database Links | Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
| Cellular Localisation | Cytoplasm Cytosol Cytoskeleton Cell Membrane Peripheral Membrane Protein Cell Projection Cilium Nucleus Speckle Nucleus Cajal Body Microtubule Organizing Center Centrosome Photoreceptor Inner Segment Detected At The Tip Of Cochlear Hair Cell Stereocilia Recruited To The Cell Membrane Via Interaction With Cdh23 Or Pcdh15 In Photoreceptor Cilia Detected Predominantly At The Cilium Base Expressed In The Pericentriolar Region Of The Centrosome |
| Alternative Antibody Names | Anti-Pre-Mrna Splicing Regulator Ush1g antibody Anti-Scaffold Protein Containing Ankyrin Repeats And Sam Domain antibody Anti-Usher Syndrome Type-1g Protein antibody Anti-USH1G antibody Anti-SANS antibody |
Information sourced from Uniprot.org