| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | UROS |
| Gene ID: | 7390 |
| Uniprot ID: | HEM4_HUMAN |
| Immunogen Region: | 1-130 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human UROS (NP_000366.1). |
| Immunogen Sequence: | MKVLLLKDAKEDDCGQDPYI RELGLYGLEATLIPVLSFEF LSLPSFSEKLSHPEDYGGLI FTSPRAVEAAELCLEQNNKT EVWERSLKEKWNAKSVYVVG NATASLVSKIGLDTEGETCG NAEKLAEYIC |
| Tissue Specificity | Ubiquitous. |
| Function | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). |
| Protein Name | Uroporphyrinogen-Iii SynthaseUroiiisUrosHydroxymethylbilane Hydrolyase CyclizingUroporphyrinogen-Iii Cosynthase |
| Database Links | Reactome: R-HSA-189451 |
| Alternative Antibody Names | Anti-Uroporphyrinogen-Iii Synthase antibodyAnti-Uroiiis antibodyAnti-Uros antibodyAnti-Hydroxymethylbilane Hydrolyase Cyclizing antibodyAnti-Uroporphyrinogen-Iii Cosynthase antibodyAnti-UROS antibody |
Information sourced from Uniprot.org