| Post Translational Modifications | Phosphorylated. Phosphorylation occurs essentially on serine residues. Phosphorylation occurs in response to androgen treatment in prostate cancer cells in a mTOR-dependent manner. Phosphorylated.hyperhosphorylated in mitochondria in a mTORC-dependent signaling pathway. Phosphorylated at Ser-372 by RPS6KB1 in a growth factor- and rapamycin-dependent manner. S6K1-mediated mitochondrial phosphorylation at Ser-372 disrupts the URI1-PPP1CC complex in the mitochondrion, relieves PPP1CC phosphatase inhibition activity and hence engages a negative feedback diminishing RPS6KB1 kinase activity, preventing sustained S6K1-dependent signaling. |
| Function | Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein. Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| Protein Name | Unconventional Prefoldin Rpb5 Interactor 1Protein Nnx3Protein Phosphatase 1 Regulatory Subunit 19Rna Polymerase Ii Subunit 5-Mediating ProteinRpb5-Mediating Protein |
| Cellular Localisation | NucleusCytoplasmMitochondrionCell ProjectionDendriteColocalizes With Pfdn2Pfdn4Ppp1ccRps6kb1 And Stap1 At Mitochondrion |
| Alternative Antibody Names | Anti-Unconventional Prefoldin Rpb5 Interactor 1 antibodyAnti-Protein Nnx3 antibodyAnti-Protein Phosphatase 1 Regulatory Subunit 19 antibodyAnti-Rna Polymerase Ii Subunit 5-Mediating Protein antibodyAnti-Rpb5-Mediating Protein antibodyAnti-URI1 antibodyAnti-C19orf2 antibodyAnti-NNX3 antibodyAnti-PPP1R19 antibodyAnti-RMP antibodyAnti-URI antibody |
Information sourced from Uniprot.org
