| Host: | Mouse |
| Applications: | IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Uroplakin-3a (200-287 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Monoclonal |
| Clone ID : | ABT-UPK3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1L |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | WB 500-2000 IHC-P 1:100-500 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UPK3A |
| Gene ID: | 7380 |
| Uniprot ID: | UPK3A_HUMAN |
| Immunogen Region: | 200-287 aa |
| Specificity: | This antibody detects endogenous levels of human Uroplakin III. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section |
| Immunogen: | Synthesized peptide derived from the human Uroplakin III at the amino acid range 200-287 |
| Function | Component of the asymmetric unit membrane (AUM).a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. |
| Protein Name | Uroplakin-3a Up3a Uroplakin Iii Upiii |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Heterodimer Formation With Upk1b Is A Prerequisite To Exit Out Of The Endoplasmic Reticulum (Er) |
| Alternative Antibody Names | Anti-Uroplakin-3a antibody Anti-Up3a antibody Anti-Uroplakin Iii antibody Anti-Upiii antibody Anti-UPK3A antibody Anti-UPK3 antibody |
Information sourced from Uniprot.org